Method for treating cancer using an antibody that inhibits notch4 signaling

摘要

The invention provides methods for treating cancer via administering to a patient having a solid tumor a therapeutically effective amount of an antibody against Delta-like ligand 4(Dll4) or other Notch pathway components. The solid tumor may comprise solid tumor stem cells.

主权项

1. A method of reducing the percentage of solid tumor stem cells relative to solid tumor cells in a solid tumor comprising solid tumor stem cells, wherein the solid tumor stem cells express the cell surface marker CD44, said method comprising contacting said solid tumor stem cells with an effective amount of an antibody that inhibits Notch4 signaling.