| 发明名称 | Method for detecting esophageal carcinoma and agent for suppressing esophageal carcinoma | ||
| 摘要 | An object of the present invention is to provide a method for detecting cancer and an agent for suppressing cell growth by identification of genes showing behaviors characteristic in cancer such as esophageal carcinoma. The present invention provides a method for detecting cancer, which comprises detecting canceration through detection of amplification of at least one gene existing in an 1q32-1q41 chromosomal region in a specimen. | ||
| 申请公布号 | US9090942(B2) | 申请公布日期 | 2015.07.28 |
| 申请号 | US201012730919 | 申请日期 | 2010.03.24 |
| 申请人 | FUJIFILM Corporation;NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY | 发明人 | Inazawa Johji;Imoto Issei;Komatsu Shuhei;Kozaki Ken-ichi;Tsuda Hitoshi |
| 分类号 | C12Q1/68 | 主分类号 | C12Q1/68 |
| 代理机构 | Birch, Stewart, Kolasch & Birch, LLP | 代理人 | Birch, Stewart, Kolasch & Birch, LLP |
| 主权项 | 1. A method for treating esophageal carcinoma in a subject, which comprises: detecting the amount of each of SMYD2 protein and p53 protein in a specimen from esophagus; detecting positive expression of SMYD2 and negative expression of p53; determining poor prognosis in a subject when p53 expression is negative and SMYD2 expression is positive; and administering to the poor prognosis subject an siRNA of an SMYD2 gene as set forth in SEQ ID NO: 3 or an antisense oligonucleotide of an SMYD2 gene (SEQ ID NO: 1). | ||
| 地址 | Tokyo JP | ||