Chaotic desynchronization of neural populations with non-pulsatile inputs

摘要

A method is provided for finding an energy-optimal stimulus which gives a positive Lyapunov exponent, and hence desynchonization, for a neural population. The method is illustrated for three different neural models. Not only does it achieve desynchronization for each model, but it also does so using less energy than recently proposed methods, suggesting a powerful alternative to pulsatile stimuli for deep brain stimulation. Furthermore, we calculate error bounds on the optimal stimulus which will guarantee a minimum Lyapunov exponent. Also, a related control strategy is developed for desynchronizing neurons based on the population's phase distribution.

主权项

1. A method of brain stimulation for treatment of a neurological disease, comprising:
(a) stimulating neurons in a brain region; (b) measuring or calculating a phase response curve for a population of interest of said stimulated neurons; and (c) calculating by a computer programmed device and using said measured or calculated phase response curve for said population of interest, stimulus parameters and waveforms to synchronize or desynchronize oscillators in said brain region.