HETEROBICYCLIC COMPOUNDS AND THEIR USE AS FGFR4 RECEPTOR INHIBITORS

摘要

Described herein are compounds of Formula (I), or a pharmaceutically acceptable salt thereof: Formula (I) wherein: (A) denotes a single or double bond; Warhead is a moiety capable of forming a covalent bond with a nucleophile; Ring A is a 5-8 membered aryl, 5-12 membered heteroaryl, 3-7 member monocyclic or bicyclic heterocyclyl; or 3-12 membered monocyclic or bicyclic cycloalkyl group; W is C or N, X and Z are each independently CH or N; Y is CH or N-R4 where R4 is H, C1-6alkyl, or 3-12 membered cycloalkyl; each of R1-R3 is, independently, halo, cyano, optionally substituted C1-6alkyl, optionally substituted C1-6alkoxy, hydroxy, oxo, amino, amido, alkyl urea, optionally substituted 3-7 member heterocyclyl; R7 is hydrogen or C1-6alkyl; or R7 together with Ring A forms a 8-12 membered bicyclic heterocyclyl optionally substituted with 1-5 occurrences of R1; m is 0-5; n is 0-5; and p is 0-2 as inhibitors of FGFR-4, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of FGFR-4.