发明名称 |
2-ALKYL-OR-ARYL-SUBSTITUTED TANSHINONE DERIVATIVES, AND PREPARATION METHOD AND APPLICATION THEREOF |
摘要 |
<p>The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and specifically relates to novel 2-alkyl- or 2-aromatic-substituted tanshinone I derivatives of formula (I) or a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments. When Z=R, said derivative is 2-alkyl-substituted tanshinone I; when Z=Ar, said derivative is 2-aryl-substituted tanshinone I; when Z=Het, said derivative is 2-heteroaryl- or 2-heterocyclyl-substituted tanshinone I.</p> |
申请公布号 |
EP2786989(A4) |
申请公布日期 |
2015.07.22 |
申请号 |
EP20120853162 |
申请日期 |
2012.11.30 |
申请人 |
HANGZHOU BENSHENG PHARMACEUTICAL CO., LTD. |
发明人 |
RONG, FRANK;XU, RONGZHEN;XIE, FUWEN;LAI, HONGXI |
分类号 |
C07D307/77;A61K31/343;A61P35/00 |
主分类号 |
C07D307/77 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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