发明名称 |
Use of RNA for reprogramming somatic cells |
摘要 |
The present invention provides methods for de-differentiating somatic cells into stem-like cells without generating embryos or fetuses. More specifically, the present invention provides methods for effecting the de-differentiation of somatic cells to cells having stem cell characteristics, in particular pluripotency, by introducing RNA encoding factors inducing the de-differentiation of somatic cells into the somatic cells and culturing the somatic cells allowing the cells to de-differentiate. |
申请公布号 |
EP2896690(A2) |
申请公布日期 |
2015.07.22 |
申请号 |
EP20150154329 |
申请日期 |
2008.12.12 |
申请人 |
BIONTECH AG;TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG- UNIVERSITÄT MAINZ GEMEINNÜTZIGE GMBH |
发明人 |
SAHIN, UGUR;POLEGANOV, MARCO;BEISSERT, TIM |
分类号 |
C12N5/16;C07K14/47;C12N5/074;C12N15/00 |
主分类号 |
C12N5/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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