Method and device for the iontophoretic delivery of a drug

摘要

An iontophoretic drug delivery device storage apparatus and a method of using that device is disclosed. The device comprises a fluid reservoir, an electrode assembly and a tray apparatus. The fluid reservoir is capable of retaining a medicament and has a sealed fluid chamber defined by at least one seal. The seal includes a weaker region and a pinch-like configuration associated with that region such that application of pressure to the fluid reservoir breaks the weaker region of the seal, releasing the retained medicament. The electrode assembly comprises an active electrode, at least two passive electrodes a medicament carrying region, and a moat region around the medicament carrying region so that once fluid is delivered from the fluid reservoir to the electrode assembly the fluid is substantially retained in the medicament carrying means.

主权项

1. An iontophoretic drug delivery device, comprising:
a fluid reservoir having a fluid seal that breaks when a compressing pressure is applied to the reservoir; a medicament retainer that is separable from the fluid reservoir; an electrode assembly separable from the fluid reservoir by removing the electrode assembly from a tray assembly and retaining the fluid reservoir in the tray assembly, the electrode assembly comprising an active electrode configured to create an electric field between the active electrode and at least two passive electrodes, wherein the electric field drives a medicament from the medicament retainer after the fluid reservoir is separated from the medicament retainer; a separator pad adjacent to and spaced from the medicament retainer by a channel configured to prevent migration of the medicament between the medicament retainer and the at least two passive electrodes; and an attachment surface for securing the electrode assembly to a surface of a patient, wherein upon securement the active electrode is spaced from the at least two passive electrodes and the at least two passive electrodes are spaced from each other.