METHOD FOR PRODUCING POLYALKYLENE GLYCOL DERIVATIVE WITH NARROW MOLECULAR WEIGHT DISTRIBUTION, AND ACETAL GROUP-CONTAINING ALCOHOL COMPOUND FOR USE THEREIN AND ALKALI METAL SALT THEREOF

摘要

A method for producing a narrow molecular weight distribution polyalkylene glycol derivative having an amino group at an end is provided and allows for polymerization of ethylene oxide under mild conditions with suppressed occurrence of diol polymer impurities includes at least the steps of polymerizing ethylene oxide by using a compound represented by the following general formula (2) and converting a polymer end to R3:;wherein R1 represents a linear, branched, or cyclic monovalent hydrocarbon group having 1 to 10 carbon atoms;R2 represents a linear or branched divalent hydrocarbon group having 1 to 5 carbon atoms;R3 represents a linear, branched, or cyclic monovalent hydrocarbon group having 1 to 20 carbon atoms;M represents sodium or potassium;m represents an integer of 1 to 5;n represents an integer of 1 to 450; andk represents an integer of 1 to 5.

主权项

1. A method for producing a narrow molecular weight distribution polyalkylene glycol derivative having an amino group at an end represented by a general formula (7) by using a compound represented by the following general formula (2) as a polymerization initiator: wherein R1 each independently represents a linear, branched, or cyclic monovalent hydrocarbon group having 1 to 10 carbon atoms; R2 represents a linear or branched divalent hydrocarbon group having 1 to 5 carbon atoms; m each independently represents an integer of 1 to 5; and M represents sodium or potassium;
H2N—CH2—R2—(OCH2CH2)n—OR3  (7) wherein R2 is the same as defined in the general formula (2); R3 represents a linear, branched, or cyclic monovalent hydrocarbon group having 1 to 20 carbon atoms; and n represents an integer of 1 to 450; comprising the steps of: a) reacting a compound represented by the formula (2) with ethylene oxide; b) reacting a reaction product of the step a) with a compound represented by a general formula (8):
R3(OCH2CH2)kX  (8)wherein R3 is the same as defined in the general formula (7);k represents an integer of 0 to 5; andX represents a halogen atom or a leaving group; and c) reductively aminating a reaction product of the step b).