本发明系提供通式(I)所示之取代联芳基化合物或其药理上容许之盐。本发明之化合物,由于具有优异的抑制肺纤维母细胞增生之作用,因此可使用作为间质性肺炎/肺纤维化之治疗药及/或预防药。;(式中,R 1 、W、R 2 及Z,系如申请专利范围及说明书中之定义。) Provided is a substituted biaryl compound represented by the general formula (I) or its pharmaceutical acceptable salt. The compound of this invention has an excellent ability to inhibit the lung fibroblast proliferation, thus can be used as a treating drug and/or preventing drug for interstitial pneumonitis/pulmonary fibrosis. ;(wherein, R 1 , W, R 2 and Z have the same meanings as in claims and specification.)