发明名称 |
Composition and method for inner ear sensory hair cell regeneration and replacement |
摘要 |
A composition and method for replacement and regeneration of hair cells of the inner ear is provided. The composition comprises an active agent in an amount effective to decrease Hesl gene expression in a tissue of the inner ear. The active agent can be short interfering RNA (siRNA) molecules encapsulated in a biodegradable nanoparticle. The method involves administering a solution to the inner ear where the solution contains an active agent in an amount effective to decrease Hesl gene expression. |
申请公布号 |
AU2011261364(B2) |
申请公布日期 |
2015.07.16 |
申请号 |
AU20110261364 |
申请日期 |
2011.06.02 |
申请人 |
HOUGH EAR INSTITUTE |
发明人 |
KOPKE, RICHARD D. |
分类号 |
C12N15/11;A61K9/50;C07H21/04;C12N5/071 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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