Methods of inducing nucleation of a material is provided. The disclosed methods comprise the steps of bringing the material to a temperature near or below a phase transition temperature and altering the pressure to induce nucleation of the material. The disclosed methods are useful in freeze-drying processes, particularly pharmaceutical freeze-drying processes.
申请公布号
EP1982133(B1)
申请公布日期
2015.07.15
申请号
EP20070750150
申请日期
2007.02.07
申请人
PRAXAIR TECHNOLOGY, INC.
发明人
GASTEYER, THEODORE, HALL, III;SEVER, ROBERT, REX;HUNEK, BALAZS;GRINTER, NIGEL;VERDONE, MELINDA, LEE