| 发明名称 | Methods and compositions for targeting polyubiquitin | ||
| 摘要 | Anti-K63-linked polyubiquitin monoclonal antibodies, and methods for using the antibodies, are provided. | ||
| 申请公布号 | US9081015(B2) | 申请公布日期 | 2015.07.14 |
| 申请号 | US201213361093 | 申请日期 | 2012.01.30 |
| 申请人 | Genentech, Inc. | 发明人 | Kelley Robert F.;Matsumoto Marissa L. |
| 分类号 | A61K39/395;G01N33/68;C07K16/18 | 主分类号 | A61K39/395 |
| 代理机构 | McNeill Baur PLLC | 代理人 | McNeill Baur PLLC |
| 主权项 | 1. An isolated antibody or antigen-binding fragment thereof that specifically binds to K63-linked polyubiquitin, comprising the HVR-H1 sequence of SEQ ID NO: 5, the HVR-H2 sequence of SEQ ID NO: 66, the HVR-H3 sequence of SEQ ID NO: 6, the HVR-L1 sequence of SEQ ID NO: 3, the HVR-L2 sequence of SEQ ID NO: 14, and the HVR-L3 sequence of SEQ ID NO: 4. | ||
| 地址 | South San Francisco CA US | ||