发明名称 |
DETERMINANTS OF CANCER RESPONSE TO IMMUNOTHERAPY |
摘要 |
Molecular determinants of cancer response to immunotherapy are described, as are systems and tools for identifying and/or characterizing cancers likely to respond to immunotherapy. The present invention encompasses the discovery that the likelihood of a favorable response to cancer immunotherapy can be predicted. The present invention further comprises the discovery that cancer cells may harbor somatic mutations that result in neoepitopes that are recognizable by a patient's immune system as non-self. The identification of one or more neoepitopes in a cancer sample is useful for determining which cancer patients are likely to respond favorably to immunotherapy, in particular, treatment with an immune checkpoint modulator. |
申请公布号 |
CA2935214(A1) |
申请公布日期 |
2015.07.09 |
申请号 |
CA20142935214 |
申请日期 |
2014.12.23 |
申请人 |
MEMORIAL SLOAN KETTERING CANCER CENTER |
发明人 |
CHAN, TIMOTHY;WOLCHOK, JEDD;SNYDER CHAREN, ALEXANDRA;MAKAROV, VLADIMIR |
分类号 |
A61K39/395;A61P35/00;G01N33/48 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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