发明名称 |
METHODS OF TREATING ALZHEIMER'S DISEASE WITH APO A-1 MILANO |
摘要 |
This invention relates to the treatment of Alzheimer's disease, the reduction of the progression of Alzheimer's disease, and the alleviation of symptoms of Alzheimer's disease by administering ApoA-1 Milano based therapies to provide anti-inflammatory, antioxidant, and lipid depleting effects to brain tissue. In particular embodiments, the method comprises administering a composition comprising an rAAV vector encoding ApoA-1 Milano or an active fragment thereof, to a mammal having Alzheimer's disease or a symptom of Alzheimer's disease. |
申请公布号 |
US2015191527(A1) |
申请公布日期 |
2015.07.09 |
申请号 |
US201414536445 |
申请日期 |
2014.11.07 |
申请人 |
CEDARS-SINAI MEDICAL CENTER |
发明人 |
Shah Prediman K. |
分类号 |
C07K14/775;C12N7/00 |
主分类号 |
C07K14/775 |
代理机构 |
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代理人 |
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主权项 |
1. A method, comprising:
providing a composition comprising an rAAV vector encoding ApoA-1 Milano or an active fragment thereof; and administering the composition to a mammal in need of treatment for Alzheimer's disease, in need of slowing the progression of Alzheimer's disease, or in need of alleviating a symptom of Alzheimer's disease, to deliver the ApoA-1 Milano or an active fragment thereof to brain tissue, to treat the Alzheimer's disease, to slow the progression of Alzheimer's disease, or to alleviate the symptom of Alzheimer's disease. |
地址 |
Los Angeles CA US |