Fluorinated derivates of 3-hydroxypyridin-4-ones

摘要

Provided are compounds of Formula I which are derivatives of 3-Hydroxypyridin-4-ones. The compounds may be used in treatment of a medical condition related to a toxic concentration of iron. The compounds may be used for preparation of a medicament for treatment of a medical condition related to a toxic concentration of iron. The medical condition related to a toxic concentration of iron may be selected from the group consisting of: cancer, pulmonary disease, progressive kidney disease and Frederich's Ataxia.

主权项

1. An amine-containing fluorinated 3-hydroxypyridin-4-(1H)-one compound of Formula I:or a salt thereof,wherein:
G1 is the amine-containing substituent —CH2NR1R2; G2 is CH2CF2R3; G3 is H or C1-C1 alkyl; G4 is H or C1-C4 alkyl, R1 and R2 are either (a) two independent groups or (b) together form a single ring group including the N to which they are bonded, where R1 and R2, when independent groups, are independently selected from the group consisting of: H, C1-C4 alkyl, C3-C6 cycloalkyl, allyl, and propargyl; or R1 and R2, when together form a single ring group including the N to which they are bonded, are selected from the group consisting of: piperazinyl, N—(C1-C4 alkyl)-substituted piperazinyl, and piperidinyl; R3 is H, or F.