| 发明名称 |
Cyclic N,N′-diarylthioureas and N,N′-diarylureas-androgen receptor antagonists, anticancer agent, method for preparation and use thereof |
| 摘要 |
The invention relates to novel N,N′-disubstituted 2-thioxo-7-oxa-1,3-diaza-spiro[4.4]nonan-4-one-androgen receptor (AR) antagonists, an anticancer agent, a pharmaceutical composition, a medicament, and a method for treating prostate cancer.;4-[3-(4-Cyano-3-trifluoromethyl-phenyl)-4-oxo-2-thioxo-7-oxa-1,3-diaza-spiro[4.4]non-1-yl]-2-fluoro-benzamide of general formula 1 and enantiomer thereof;wherein:R represents C1-C3alkyl. |
| 申请公布号 |
US9073874(B2) |
申请公布日期 |
2015.07.07 |
| 申请号 |
US201113811282 |
申请日期 |
2011.07.01 |
| 申请人 |
|
发明人 |
Ivachtchenko Alexandre Vasilievich;Mitkin Oleg Dmitrievich |
| 分类号 |
A61K31/505;C07D233/86;C07D233/72;C07D239/10;C07D239/22;C07D249/12;C07D471/10;C07D491/107;A61K9/00;A61K9/20;A61K9/48 |
主分类号 |
A61K31/505 |
| 代理机构 |
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代理人 |
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| 主权项 |
1. A 4-[3-(4-Cyano-3-trifluoromethyl-phenyl)-4-oxo-2-thioxo-7-oxa-1,3-diaza-spiro[4.4]non-1-yl]-2-fluoro-benzamide compound of general formula 1 wherein: R represents C1-C3alkyl, and enantiomers thereof. |
| 地址 |
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