| 主权项 |
1. A crystalline Form A of 1-(5′-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3′H-spiro[azetidine-3,1′-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethanone which exhibits at least one of the following properties:
a) an X-ray diffraction pattern having characteristic peaks expressed in degrees 2θ (±0.2°) at about 17.18, 18.83, and 20.07; b) an X-ray diffraction pattern having characteristic peaks expressed in degrees 2θ (±0.2°) at about 17.18, 18.83, and 20.07, and further comprising at least one additional diffraction peak expressed in degrees 2θ (±0.2°) selected from the group consisting of peaks at about 4.70, 9.39, 14.10, 15.70, 19.12, 20.97, 21.42, 22.03, 22.54, 23.62, and 28.42; c) an X-ray diffraction pattern having characteristic peaks expressed in degrees 2θ (±0.2°) at about 17.18, 18.83, and 20.07, and further comprising at least one additional diffraction peak expressed in degrees 2θ (±0.2°) at about 21.42, 22.54, and 28.42; d) an X-ray diffraction pattern having characteristic peaks expressed in degrees 2θ (±0.2°) at about 17.18, 18.83, 20.07, 21.42, 22.54, and 28.42; e) a Fourier Transform infrared spectrum at the 1800 to 600 cm−1 range, substantially as shown in FIG. 2; f) a differential scanning calorimeter thermogram having a single predominant endotherm at about 145.53° C. at a scan rate of 10° C. per minute, substantially as shown in FIG. 3.1; and g) a differential scanning calorimeter thermogram having a single predominant endotherm within the range of 144.01 to 146.92° C. at a scan rate of 10° C. per minute, substantially as shown in FIG. 3.2. |
