NOVEL METHOD FOR PREPARING TELMISARTAN

摘要

The present invention relates to a method for preparing telmisartan used as an angiotensin-II receptor blocker (ARB)-based hypertension medicine and telmisartan prepared by the method. According to the method of the present invention, a condensation reaction for obtaining an intermediate during a telmisartan preparing procedure is conducted in a solvent containing an ionic liquid, thereby significantly shortening the reaction time by 1-2 hours compared with the conventional method; and a hydrolysis reaction of the intermediate for preparing telmisartan is conducted by controlling the ratio of water containing a hydroxyl group, thereby significantly improving filtering efficiency, the process rate, and process convenience and obtaining high-purity and high-yield telmisartan without further purification.