Humanized antibodies to liv-1 and use of same to treat cancer

摘要

Disclosed is a humanised antibody comprising a mature heavy chain variable region having an amino acid sequence at least 90 % identical to SEQ ID NO:53 provided that position H27 is occupied by L, position H29 is occupied by I, H30 by E and H94 by V and a mature light chain variable region at least 90 % identical to SEQ ID NO:60 provided position L36 is occupied by Y and position L46 by P; wherein the sequences are as defined in the specification. Also disclosed is its use in treating cancer.