Neuromodulation cryotherapeutic devices and associated systems and methods

摘要

Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment includes an elongated shaft and a cooling assembly at a distal portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site within or otherwise proximate a renal artery. The cryotherapeutic device can further include a supply lumen configured to carry liquid refrigerant toward the cooling assembly. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when in a deployed state.

主权项

1. A cryotherapeutic device, comprising:
an elongated shaft having a distal portion, the shaft being configured to locate the distal portion intravascularly at a treatment site within or otherwise proximate a renal artery; a cooling assembly at the distal portion of the shaft, the cooling assembly having a low-profile delivery state and an expanded deployed state, the cooling assembly including an applicator having a first balloon that defines a chamber, and a second balloon adjacent to the first balloon and configured to thermally insulate a region of tissue at the treatment site from the first balloon when the cooling assembly is in the deployed state; a supply tube configured to carry liquid refrigerant distally to the chamber along at least a portion of the shaft; and an exhaust tube configured to carry gaseous refrigerant proximally from the chamber along at least a portion of the shaft, wherein the second balloon is more complaint than the first balloon.