发明名称 |
C20'-urea derivatives of Vinca alkaloids |
摘要 |
A vinca alkaloid compound that is substituted at the 20'-position with a urea or thiourea group is disclosed. The urea's proximal nitrogen atom bonded to the 20'-position carbon atom is secondary, whereas the distal nitrogen atom can be unsubstituted only when the compound contains an optionally present 10'-fluoro substituent, and is otherwise preferably mono- or di-substituted. Methods of preparing the compounds are disclosed as are compositions for their use and methods of treatment using a compound. |
申请公布号 |
AU2013356664(A1) |
申请公布日期 |
2015.06.18 |
申请号 |
AU20130356664 |
申请日期 |
2013.08.23 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
BOGER, DALE L. |
分类号 |
C07D471/22;A61K31/4375;A61P35/00;C07D471/14 |
主分类号 |
C07D471/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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