DEUTERATED CARFILZOMIB

摘要

The present invention in one embodiment provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula (I) are as defined in the specification. The compound of Formula (I) is useful for the treatment of diseases such as a disease selected from the group consisting of multiple myeloma, solid tumors, lymphoma, and leukemia.;

主权项

1. A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: each of R1, R2, R3, R4 and R5 is independently selected from CH3 and CD3; each Y1 is the same and is hydrogen or deuterium; each Y2 is the same and is hydrogen or deuterium; each Y3 is the same and is hydrogen or deuterium; each Y4 is the same and is hydrogen or deuterium; Y5 is hydrogen or deuterium; each Y6 is the same and is hydrogen or deuterium; Y7 is hydrogen or deuterium; each Y8 is the same and is hydrogen or deuterium; and Y9 is hydrogen or deuterium; provided that if each of R1, R2, R3, R4 and R5 is CH3; each Y1 is hydrogen; each Y2 is hydrogen; each Y3 is hydrogen; each Y4 is hydrogen; Y5 is hydrogen; each Y6 is hydrogen; Y7 is hydrogen; and each Y8 is hydrogen; then Y9 is deuterium.