MONOCLONAL ANTIBODY HAVING IMMUNOSUPPRESSIVE ACTIVITY OR FRAGMENT TO WHICH ANTIGEN THEREOF IS BONDED

摘要

The present invention relates to a monoclonal antibody having immunosuppressive activity or a fragment to which an antigen of the monoclonal antibody is bonded. In particular the present invention relates to a monoclonal antibody that couples with a conjugate of a peptide comprising an amino acid sequence represented by SSVLYGGPPSAA (SEQ ID NO: 1) or with a conjugate of a carrier which is pharmaceutically acceptable with the peptide or relates to a fragment to which an antigen of the monoclonal antibody is bonded wherein the monoclonal antibody or the fragment to which an antigen of the monoclonal antibody is bonded has a greater binding affinity for core histones than for histone H1.