COMPOSITIONS AND METHODS FOR PROGNOSIS AND TREATMENT OF CANCER

摘要

A method of diagnosing and/or treating a patient diagnosed with breast cancer includes the steps of: (a) identifying a patient as having a triple negative breast cancer; (b) obtaining a sample from the triple negative breast cancer patient comprising breast cancer cells; and (c) determining whether the cells in the sample express an elevated level of nuclear HSET, wherein an elevated level indicates a poorer prognosis. The method may further include the step of determining whether the cells in the sample express elevated level(s) of one or more products upregulated with HSET, elevated levels of phosphorylated histone-H3 and/or exhibit enhanced Cdk1 activity. In certain embodiments, the method further includes the step of administering one or more therapeutic agents, such as HSET inhibitors, centrosome declustering agents, PARP inhibitors, Ras/MAPK pathway inhibitors, PI3K/AKT/mTOR pathway inhibitors or a combination thereof.

主权项

1. A method of assessing the prognosis of a patient diagnosed with triple negative breast cancer, the method comprising:
performing an assay on a biological sample comprising breast cancer cells from said patient to determine whether said breast cancer cells express an elevated level of nuclear HSET; and providing an assessment of the prognosis of said patient based on the result of said assay, wherein an elevated level of nuclear HSET in said breast cancer cells indicates a poorer prognosis for said patient compared to a patient with triple negative breast cancer expressing a lower level of nuclear HSET.