发明名称 |
USE OF MIR-494 TO MODULATE TRAIL-INDUCED APOPTOSIS THROUGH BIM DOWN-REGULATION |
摘要 |
Methods and compositions for inhibiting tumorigenicity both in vitro and in vivo in a subject in need thereof, comprising administering an effective amount of an anti-miR-494 nucleic acid construct sufficient to target one or more tumor suppressor genes (TSGs) are described. Activation of the ERKl/2 pathway is a major determinant of diverse cellular processes and cancer development and is responsible for the transcription of several important miRNAs. Described herein is a link between the ERK1/2 pathway and BIM expression through miR-494. This ERK1/2 pathway regulates apoptosis and cell proliferation through miR-494 and mechanisms responsible for TRAIL resistance. Materials and methods related to the study and treatment of cancer are described. |
申请公布号 |
WO2014047546(A3) |
申请公布日期 |
2015.06.11 |
申请号 |
WO2013US61157 |
申请日期 |
2013.09.23 |
申请人 |
THE OHIO STATE UNIVERSITY |
发明人 |
CROCE, CARLO, M.;GIULIA, ROMANO |
分类号 |
A61K48/00;C12Q1/68 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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