MICRORNAs SENSITIZE CANCERS TO THERAPY

摘要

The present invention concerns methods and compositions regarding one or more microRNAs or variants thereof that are provided to an individual for a variety of medical treatments, including sensitization to cancer therapy or prevention of a cancer to become sensitized to a cancer therapy. In specific embodiments, the microRNAs include miR-520a (including at least miR-520a-3p and miR-520-5p), miR-520g, miR-520h, and functional variants thereof. In some embodiments, the cancer is ovarian cancer, and in particular embodiments, the cancer therapy is platinum-based chemotherapy.

主权项

1. A method of sensitizing a cancer in an individual to a cancer treatment, comprising the step of administering to the individual an effective amount of a composition as follows:
a) a RNA polynucleotide comprising SEQ ID NO:1, SEQ ID NO:2, or SEQ ID NO:3; or b) a RNA polynucleotide comprising sequence having one or more nucleotide alterations in SEQ ID NO:1, SEQ ID NO:2, or SEQ ID NO:3, wherein upon administering the composition to the individual, the cancer is thereby sensitized to the treatment.