发明名称 |
MODIFIED RNAI AGENTS |
摘要 |
One aspect of the present invention relates to double-stranded RNAi (dsRNA) duplex agent capable of inhibiting the expression of a target gene in vivo. The dsRNA duplex comprises one or more xylo modifications in one or both strand. Other aspects of the invention relates to pharmaceutical compositions comprising these dsRNA agents suitable for in vivo therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA agents, e.g., for the treatment of various disease conditions. |
申请公布号 |
EP2880162(A2) |
申请公布日期 |
2015.06.10 |
申请号 |
EP20130747932 |
申请日期 |
2013.08.02 |
申请人 |
ALNYLAM PHARMACEUTICALS, INC. |
发明人 |
RAJEEV, KALLANTHOTTATHIL, G.;MANOHANRAN, MUTHIAH |
分类号 |
C12N15/113;C07H21/02;C12N15/11 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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