Pharmaceutical composition for treatment of corneal endothelial wounds containing angiogenin

摘要

Provided is a pharmaceutical composition for treating corneal endothelium wounds, the composition including angiogenin as an effective ingredient. The present invention relates to a new topical therapeutic use of angiogenin for treatment of corneal endothelium wounds, wherein the angiogenin that is generally known to be involved in angiogenesis activates a PI3K/Akt/eNOS pathway thereof in ocular corneal endothelium to increase migration and proliferation of corneal endothelial cells that are not capable of self-proliferation and to promote prevention and treatment of corneal endothelial cell wounds.

主权项

1. A method of treating one or more corneal endothelium wounds in a subject in need thereof, comprising:
a) providing a pharmaceutical composition comprising a therapeutically effective amount of angiogenin as an active ingredient; and b) administering the composition of step (a) to the cornea of the subject, wherein the wound or wounds are treated.