Process and intermediates for preparing GPR40 agonists

摘要

The present invention relates to compounds of formula I;
wherein RS denotes F or CF3, Ra denotes H or C1-4-alkyl and Z denotes a leaving group or an optionally substituted or protected hydroxyl group, suitable as intermediates in the synthesis of indanyloxydihydrobenzofuranylacetic acids, which are GPR40 agonists, to a process for preparing these intermediates and to the process for preparing the GPR40 agonists making use of an asymmetric catalytic hydrogenation reaction in the presence of a transition metal catalyst and a chiral auxiliary.

主权项

1. A compound of formula (I)wherein:
RS is F or CF3; Ra is H or C1-4-alkyl; and Z is a leaving group or an optionally protected hydroxyl group, or a salt of the compound of formula (I) wherein Ra is H.