| 发明名称 |
Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes, and parkinson's |
| 摘要 |
The use of 3,4,3′,4′-tetrahydroxychalcone in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease. |
| 申请公布号 |
US9051253(B2) |
申请公布日期 |
2015.06.09 |
| 申请号 |
US201313887762 |
申请日期 |
2013.05.06 |
| 申请人 |
PROTEOTECH INC. |
发明人 |
Snow Alan D.;Nguyen Beth;Castillo Gerardo;Sanders Virginia;Lake Thomas;Larsen Lesley |
| 分类号 |
A61K31/047;A61K31/05;C07C49/248;C07C39/15;C07C39/16;C07C39/17;C07C45/62;C07C45/64;C07C49/83;C07C49/835;C07C69/017;C07C215/50;C07C231/02;C07C235/34;C07C235/38;C07C235/48;C07C235/54;C07C235/56;C07C237/22;C07C275/34;C07D207/16;C07D211/74;C07D213/30;C07D213/69;C07D213/85;C07D221/08;C07D221/18;C07D231/06;C07D241/08;C07D263/38;C07D265/38;C07D295/096;C07D295/192;C07D311/60;C07D317/50;C07D317/54;C07D317/58;C07D317/60;C07D317/66;C07D317/68;C07D333/16;C07D405/14;C07D407/14;C07D409/14;C07D413/14;C07D451/06;C07D471/04;C07D487/08;C07D491/08 |
主分类号 |
A61K31/047 |
| 代理机构 |
|
代理人 |
Eagen Rebecca |
| 主权项 |
1. A method of relieving a amyloid disease or a synucleinopathy in a mammal suffering therefrom, comprising administration to the mammal of a therapeutically effective amount of 3,4,3′,4′-tetrahydroxychalcone, wherein the synucleinopathy is Parkinson's disease. |
| 地址 |
Kirkland WA US |
