发明名称 |
DUAL-ACTING PHARMACEUTICAL COMPOSITIONS BASED ON SUPERSTRUCTURES OF ANGIOTENSIN RECEPTOR ANTAGONIST/BLOCKER (ARB) AND NEUTRAL ENDOPEPTIDASE (NEP) INHIBITOR |
摘要 |
<p>Solid oral dosage forms, especially tablets, of a pharmaceutical composition comprising a supramolecular complex can be formed from a direct compression process or a compaction process such as roller compaction. Such solid oral dosage forms feature an immediate release profile that allows for fast release of the therapeutic agent. A particularly useful supramolecular complex is trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl) propionate-(S)-3'-methyl-2'-(pentanoyl{2"-(tetrazol-5-ylate)biphenyl-4'-ylmethyl}amino)butyrate]hemipentahydrate.</p> |
申请公布号 |
PT2217205(E) |
申请公布日期 |
2015.06.08 |
申请号 |
PT20080848154T |
申请日期 |
2008.11.04 |
申请人 |
NOVARTIS AG |
发明人 |
ALAN EDWARD ROYCE;COLLEEN RUEGGER;SULIMAN AL-FAYOUMI;JIAHUI HU;NATRAJAN KUMARAPERUMAL;ERIKA AINA ZANNOU |
分类号 |
A61K9/00;A61K9/20;A61K31/216 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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