摘要 |
<p>Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein: W is O, N-H, N-(C1-C10 alkyl) or S; each X is independently CH or N; R1 is a 5 to 7-membered saturated or unsaturated, optionally substituted heterocycle containing at least 1 heteroatom selected from N or O; R2 is (LQ)mY; and each R3 is independently H, C1-C10 alkyl, aryl or heteroaryl, are surprisingly found to be inhibitors of PI3K-p1 106, and therefore have utility in therapy.</p> |
申请人 |
KARUS THERAPEUTICS LIMITED |
发明人 |
SHUTTLEWORTH, STEPHEN, JOSEPH;CECIL, ALEXANDER RICHARD LIAM;HILL, THOMAS JAMES;SILVA, FRANCK ALEXANDRE |