LIQUID FORMULATIONS FOR TREATMENT OF DISEASES OR CONDITIONS

摘要

Described herein are liquid formulations which deliver a variety of therapeutic agents, including but not limited to rapamycin, to a subject for an extended period of time; liquid formulations which form a non-dispersed mass when placed in an aqueous medium of a subject; liquid formulations comprising a therapeutic agent and a plurality of polymers; and methods for delivering therapeutic agents to a subject for an extended period of time using the liquid formulations. The liquid formulation may be placed in an aqueous medium of a subject, including but not limited to via intraocular or periocular administration. A method may be used to administer rapamycin to treat or prevent angiogenesis, choroidal neovascularization, or age-related macular degeneration in a subject.

主权项

1. A method for treating age-related macular degeneration (AMD) in a human subject, the method comprising
administering to the human subject by intravitreal injection a volume of a liquid formulation comprising an effective amount of a therapeutic agent to treat AMD in the human subject for at least one month, wherein the liquid formulation comprises between 0.5% (w/w) to 6.0% (w/w) of the therapeutic agent, between 80% (w/w) to 99% (w/w) of polyethylene glycol, and ethanol, the therapeutic agent is rapamycin or a pharmaceutical acceptable salt thereof, the AMD is selected from the group consisting of dry form of AMD, wet form of the AMD and transition from the dry form of AMD to the wet form of AMD, and the liquid formulation is a liquid solution that forms a non-dispersed mass when injected into the vitreous.