| 发明名称 |
CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS CLUMPING FACTOR A IN COMPLEX WITH FIBRINOGEN DERIVED PEPTIDE AND USES THEREOF |
| 摘要 |
The present invention discloses crystal structure of Staphylococcus aureus Clumping factor A (ClfA) in complex with fibrinogen (Fg) derived peptide. Also, the present invention also discloses the use of this structure in the design of ClfA targeted vaccines and therapeutic agents (including monoclonal antibodies). In addition, the present invention discloses isolated and purified engineered Staphylococcus clumping factor A protein (ClfA) with a stabilized, closed conformation and immunogenic compositions thereof including methods of treating a Staphylococcus infection in an individual. |
| 申请公布号 |
US2015152174(A1) |
申请公布日期 |
2015.06.04 |
| 申请号 |
US201514618734 |
申请日期 |
2015.02.10 |
| 申请人 |
THE TEXAS A & M UNIVERSITY SYSTEM |
发明人 |
Hook Magnus;Ko Ya-Ping;Smeds Emanuel;Ganesh Vannakambadi K. |
| 分类号 |
C07K16/18;C07K16/12 |
主分类号 |
C07K16/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An anti-MSCRAMM:fibrinogen antibody effective to inhibit MSCRAMM:fibrinogen interaction but does not affect binding of other proteins to fibrinogen. |
| 地址 |
College Station TX US |
