发明名称 |
Small molecule bicyclic and tricyclic CFTR correctors |
摘要 |
<p>Novel CFTR corrector compounds that are effective in rescuing halide efflux, delF508-CFTR protein processing, and apical functional chloride ion transport in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of rescuing halide efflux in a cell, correcting a processing defect of a delF508-CFTR protein in a cell, and correcting functional delF508-CFTR chloride channels in a cell are also provided.</p> |
申请公布号 |
AU2013348019(A1) |
申请公布日期 |
2015.06.04 |
申请号 |
AU20130348019 |
申请日期 |
2013.11.20 |
申请人 |
DISCOVERYBIOMED, INC. |
发明人 |
SCHWIEBERT, ERIK;STREIFF, JOHN;DIXON, JOHN;GAO, HONGWU |
分类号 |
C07D487/14;A61K31/519;A61K31/53;A61P11/12;C07D487/04;C07D495/14;C07D498/14 |
主分类号 |
C07D487/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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