| 摘要 |
The present invention is directed to bicyclic pyrrole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by GPR120. More particularly, the compounds of the present invention are agonists of GPR120, useful in the treatment of, such as for example, Type II diabetes mellitus. |
| 主权项 |
1. A compound of formula (I) wherein R1 is selected from the group consisting of phenyl and pyridinyl; wherein the phenyl or pyridinyl is optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, carboxy, —C(O)O—(C1-4alkyl), —C(O)—(C1-4alkyl), C1-4alkyl, fluoro substituted C1-4alkyl, C1-4alkoxy and fluoro substituted C1-4alkoxy; R2 is selected from the group consisting of hydrogen, halogen, cyano, C1-4alkyl and fluoro substituted C1-4alkyl; a is in integer from 0 to 3; each R3 is independently selected from the group consisting of halogen, C1-4alkyl, fluoro substituted C1-4alkyl, and cyano; provided that when a is 2 or 3, then only one R3 can be cyano; R4 is selected from the group consisting of hydrogen and methyl; R5 is selected from the group consisting of —CH2OH and —C(O)OH; or a pharmaceutically acceptable salt thereof. |
