发明名称 |
Therapeutic agent for cancer |
摘要 |
The present invention provides an adjuvant for cancer antigen peptide vaccines and virus antigen peptides, containing a pertussis vaccine as a primary ingredient. The present invention also provides a therapeutic agent for a cancer or viral infectious disease, and a prophylactic agent for metastasis or recurrence of cancer or onset of virus-induced tumor, containing a cancer antigen peptide or virus antigen peptide and a pertussis vaccine. A pertussis vaccine that can be suitably used is a whole cell body pertussis vaccine. The agents of the present invention can be safely administered in a plurality of doses. |
申请公布号 |
US9045556(B2) |
申请公布日期 |
2015.06.02 |
申请号 |
US200812449377 |
申请日期 |
2008.02.07 |
申请人 |
NEC Corporation;The Research Foundation for Microbial Disease of Osaka University;National University Corporation Kochi University |
发明人 |
Udaka Keiko;Ishibashi Masahide |
分类号 |
A61K39/10;A61K39/00;A61K39/04;C07K14/47;A61K39/02 |
主分类号 |
A61K39/10 |
代理机构 |
Wenderoth, Lind & Ponack, L.L.P. |
代理人 |
Wenderoth, Lind & Ponack, L.L.P. |
主权项 |
1. A therapeutic agent for malignant tumor or a prophylactic agent for malignant tumor metastasis or recurrence, comprising WT1 or a peptide comprising a portion of the amino acid sequence thereof, wherein the peptide consists of the amino acid sequence shown in SEQ ID NO:2 or SEQ ID NO:4, a pertussis vaccine, and a carrier, the pertussis vaccine is a whole cell pertussis vaccine, and the whole cell pertussis vaccine is an adjuvant,
wherein the peptide is present in the agent in an amount of 0.1 to 5 mg and the vaccine is present in an amount of 1×108 to 1×109 cells of the whole cell pertussis vaccine. |
地址 |
Tokyo JP |