| 发明名称 | Compositions and methods for treatment | ||
| 摘要 | The present invention provides compounds and methods for the treatment of LFA-1 mediated diseases. In particular, LFA-1 antagonists are described herein and these antagonists are used in the treatment of LFA-1 mediated diseases. One aspect of the invention provides for diagnosis of an LFA-1 mediated disease and administration of a LFA-1 antagonist, after the patient is diagnosed with a LFA-1 mediated disease. In some embodiments, the LFA-1 mediated diseases treated are dry eye disorders. Also provided herein are methods for identifying compounds which are LFA-1 antagonists. | ||
| 申请公布号 | US9045458(B2) | 申请公布日期 | 2015.06.02 |
| 申请号 | US201414275159 | 申请日期 | 2014.05.12 |
| 申请人 | SARcode Bioscience Inc. | 发明人 | Zhong Min;Shen Wang;Oslob Johan D.;Barr Kenneth |
| 分类号 | C07D405/06;C07D217/00;A61K31/198;A61K31/404;A61K31/4162;A61K31/4184;A61K31/4192;A61K31/44;A61K31/4709;A61K31/4725;A61K31/4745;A61K31/496;A61K31/5377;A61K31/54;A61K31/541;A61K31/381;A61K45/06;C07D333/38;C07D405/14;C07D409/14;C07D471/04;A61K33/00;A61K33/06;C07D217/20;C07D217/06 | 主分类号 | C07D405/06 |
| 代理机构 | Troutman Sanders LLP | 代理人 | Troutman Sanders LLP |
| 主权项 | 1. A compound having the following formula:or a pharmaceutically acceptable salt thereof. | ||
| 地址 | Bisbane CA US | ||