Derivados de 2H-piridazin-3-onas, su preparación y su utilización como inhibidores de la SCD-1

摘要

The present invention concerns compounds of general formula (I) characterized in that (formula 1) wherein, in particular:—R1 represents one or more groups such as: trifluoromethyl, halogen such as F, Cl,—when n=m=1, W represents CH then Y represents oxygen,—U represents:•either—(C═O)CH2NH—and is branched at position 4 of pyridazinone, then R2 represents H,•or—(C═O)NH—and U is branched at positions (4), (5) or (6) of pyridazinone, then R2 represents H,—R3 represents a hydrogen or methyl and the addition salts with pharmaceutically acceptable bases and acids and the different isomers, and their mixtures in any proportion for use as SCD-1 enzyme inhibitors for the treatment of obesity, type-2 diabetes and lipid disorders.