| 摘要 |
Disclosed is a live attenuated virus composition comprising: one or more live, attenuated viruses wherein the viruses are enveloped viruses; one or more poly(ethylene oxide) and poly(propylene oxide) (EO-PO) block copolymers, the one or more EO-PO block copolymers include one or more of poloxamer 338 (P108), poloxamer 105 (P105) and poloxalene F88 wherein the EO-PO block copolymer is not poloxamer 407, one or more proteins agents, the one or more protein agents are one or more albumins selected from the group consisting of lactalbumins and serum albumins, and one or more carbohydrate agents, the one or more carbohydrate agents include trehalose, wherein the composition is capable of reducing the inactivation of the live attenuated virus. Also disclosed is a method for decreasing inactivation of a live attenuated virus. |
