| 摘要 |
PROBLEM TO BE SOLVED: To provide compounds useful for inhibition of CHK1 and/or CHK2.SOLUTION: Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. In one aspect, the present invention relates to compounds that are inhibitors of CHK1 and/or CHK2. Accordingly, the compounds of the present invention are useful in treatment of diseases and conditions that can be treated by inhibition of CHK1 and/or CHK2 protein kinases. |
