| 摘要 |
<p>The present invention relates to, inter alia, methods for culturing mesenchymal stem cells (MSCs) (without the use of non-human serum components), MSCs and extracellular vesicles obtained from such culturing methods, having advantageous polypeptide profiles which are key for immuno-modulatory efficacy. Further, the present invention pertains to pharmaceutical compositions comprising such MSCs and/or extracellular vesicles, and medical treatment and prophylactic methods and medical uses of MSCs and/or extracellular vesicles in a variety of diseases, notably myocarditis, pericarditis, cardiomyopathy and specifically dilated cardiomyopathy, and/or post-cardiotomy syndrome, and related diseases and ailments, such as organ failure.</p> |
