ANTI-DENGUE VIRUS GENETIC VACCINE BASED ON THE ENVELOPE PROTEIN ECTODOMAINS

摘要

The present invention refers to a genetic vaccine for dengue virus of all serotypes or for any virus belonging to the Flavivirus genus. Said vaccine is based on the envelope protein E ectodomains, more in particular on the DIII domain of dengue virus or of other Flavivirus. A genetic construct encoding a fusion protein wherein said domain of envelope protein E is fused to a carboxyterminal domain from the constant region of an immunoglobulin is disclosed in the present invention. The use of said construct allows for an efficient secretion of the fusion protein from the cells and thus for a high antibody response.