发明名称 |
WEEKLY DOSING REGIMENS FOR ANTI-CD30 VC-PAB-MMAE ANTIBODY DRUG-CONJUGATES |
摘要 |
Methods for the treatment of CD30-expressing cancers are provided. The methods comprise administering to a subject in need thereof a weekly dose of from about 0.8 mg/kg to about 1.8 mg/kg of an antibody-drug conjugate compound having formula (I); or a pharmaceutically acceptable salt thereof; wherein: mAb is an anti-CD30 antibody unit, S is a sulfur atom of the antibody, A- is a Stretcher unit, and p is from about 3 to about 5. |
申请公布号 |
EP2376110(A4) |
申请公布日期 |
2015.05.20 |
申请号 |
EP20100729571 |
申请日期 |
2010.01.08 |
申请人 |
SEATTLE GENETICS, INC. |
发明人 |
SIEVERS, ERIC;KENNEDY, DANA;IHLE, NATHAN;SUN, MICHAEL |
分类号 |
A61K39/00;C07K17/14;C12N5/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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