| 发明名称 | Syndecan peptides and polypeptides as inhibitors of cancer | ||
| 摘要 | The invention provides for peptides from syndecan 1 and methods of use therefor. These peptides can inhibit α4β6 interaction with HER2, thereby preventing tumor cell growth and tissue invasion. | ||
| 申请公布号 | US9034827(B2) | 申请公布日期 | 2015.05.19 |
| 申请号 | US201313936854 | 申请日期 | 2013.07.08 |
| 申请人 | Wisconsin Alumni Research Foundation | 发明人 | Rapraeger Alan |
| 分类号 | A61K38/00;C07K14/47 | 主分类号 | A61K38/00 |
| 代理机构 | Parker Highlander PLLC | 代理人 | Parker Highlander PLLC |
| 主权项 | 1. A method of inhibiting α6β4 integrin interaction with HER2/Neu on the surface of a cancer cell comprising administering to said subject a peptide segment consisting of between 26 and 100 amino acid residues and comprising 210-235 of SEQ ID NO:1 such that the surface of said cancer cell is contacted by said peptide. | ||
| 地址 | Madison WI US | ||