| 发明名称 | Injectable chitosan mixtures forming hydrogels | ||
| 摘要 | A chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of acetylation in the range of from about 30% to about 60%, and at least one type of chitosan having a degree of deacetylation of at least about 70% is disclosed. Further disclosed is a chitosan composition which forms a hydrogel at near physiological pH and 37° C., that includes at least one type of chitosan having a degree of deacetylation of at least about 70% and a molecular weight of from 10-4000 kDa, and at least one type of a chitosan having a molecular weight of from 200-20000 Da. Further disclosed are methods of preparation and uses of the chitosan compositions. | ||
| 申请公布号 | US9034348(B2) | 申请公布日期 | 2015.05.19 |
| 申请号 | US201313830268 | 申请日期 | 2013.03.14 |
| 申请人 | Chi2Gel Ltd. | 发明人 | Ben-Shalom Noah;Nevo Zvi;Patchornik Abraham;Robinson Dror |
| 分类号 | A61K9/00;A61K47/36;A61L26/00;A61K31/738;A61L27/20;A61L27/52;A61L27/60;A61K8/73;A61Q19/00;A61K9/06;A61K8/04;C08J3/075;C08L5/08;A61L27/38;A61Q19/08 | 主分类号 | A61K9/00 |
| 代理机构 | Winston & Strawn LLP | 代理人 | Winston & Strawn LLP |
| 主权项 | 1. A chitosan composition which forms a hydrogel at near physiological pH and at 37° C., comprising at least one acetylated chitosan having a degree of acetylation in the range of from about 30% to about 60%, and at least one deacetylated chitosan having a degree of deacetylation that is about 70% to about 95%, the composition being in the form of an aqueous solution at neutral pH, wherein the ratio of said acetylated chitosan to said deacetylated chitosan in the composition is in the range of 1:1 to 4:1. | ||
| 地址 | Tel Aviv IL | ||