| 发明名称 |
INFLUENZA VIRUS VACCINES AND USES THEREOF |
| 摘要 |
Provided herein are flu hemagglutinin polypeptides, including chimeric influenza virus hemagglutinin polypeptides, and flu hemagglutinin polypeptides comprising modified glycosylation sites and non-naturally glycosylation sites, compositions comprising the same, vaccines comprising the same and methods of their use. |
| 申请公布号 |
US2015132330(A1) |
申请公布日期 |
2015.05.14 |
| 申请号 |
US201214345816 |
申请日期 |
2012.09.19 |
| 申请人 |
MOUNT SINAI SCHOOL OF MEDICINE |
发明人 |
Garcia-Sastre Adolfo;Palese Peter;Krammer Florian;Pica Natalie;Eggink Dirk;Medina-Silva Rafael A.;Hai Rong |
| 分类号 |
C07K14/005;A61K39/145;C12N7/00 |
主分类号 |
C07K14/005 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A chimeric influenza virus hemagglutinin (HA) polypeptide comprising an HA stem domain and an HA globular head domain, wherein the HA globular head domain is heterologous to the HA stem domain. |
| 地址 |
New York NY US |
