发明名称 |
MAGNETIC MICROBUBBLES, METHODS OF PREPARING THEM AND THEIR USES |
摘要 |
The invention provides a method of preparing a suspension of microbubbles for use in a carrier liquid, wherein the microbubbles have a gas core and a liquid shell, said liquid shell comprising magnetic nanoparticles, and wherein the microbubbles satisfy the following conditions: (i) the force due to buoyancy (FBW) of the microbubble in the carrier liquid is greater than the weight (W) of the microbubble; (ii) the magnetic force (FM) on the microbubble due to a magnetic field applied to the carrier liquid is greater than the combined weight (W) and force due to buoyancy (FBW) of the microbubble; (iii) said magnetic force (FM) on the microbubble is greater than the force due to viscous drag (FD) on the microbubble due to flow of the carrier liquid; and (iv) the scattering cross section (&sgr;scat) of the microbubble to ultrasound allows the microbubble to be detectable and rupturable on exposure to ultrasound. |
申请公布号 |
EP2296620(B1) |
申请公布日期 |
2015.05.13 |
申请号 |
EP20090769584 |
申请日期 |
2009.06.26 |
申请人 |
UCL BUSINESS PLC |
发明人 |
PANKHURST, QUENTIN, ANDREW;STRIDE, ELEANOR, PHOEBE, JANE;PORTER, COLIN, DAVID;PRIETO GARCÍA, ANA |
分类号 |
A61K49/22;A61K9/00;A61K9/50 |
主分类号 |
A61K49/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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