| 发明名称 | Conformationally restricted urea inhibitors of soluble epoxide hydrolase | ||
| 摘要 | Inhibitors of the soluble epoxide exemplary hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases. | ||
| 申请公布号 | US9029550(B2) | 申请公布日期 | 2015.05.12 |
| 申请号 | US201313918837 | 申请日期 | 2013.06.14 |
| 申请人 | The Regents of the University of California | 发明人 | Hammock Bruce D.;Jones Paul D.;Morisseau Christophe;Huang Huazhang;Tsai Hsing-Ju;Gless, Jr. Richard |
| 分类号 | C07D211/60;C07D211/58;C07D209/08;C07D211/26;C07D211/96;C07D213/40;C07D235/30;C07D295/20;C07D295/205;C07D401/06;C07D401/12;C07D487/18;C12Q1/34 | 主分类号 | C07D211/60 |
| 代理机构 | DLA Piper LLP (US) | 代理人 | DLA Piper LLP (US) |
| 主权项 | 1. A compound having the formula: wherein R1 is phenyl, optionally substituted with from 1 to 2 substituents each independently selected from the group consisting C1-C8haloalkyl, and C1-C8haloalkoxy; L is —CO—; R4 is selected from the group consisting of C1-C8alkyl, C1-C8haloalkyl and C3-C12cycloalkyl; and the subscript n is 0; or a pharmaceutically acceptable salt thereof. | ||
| 地址 | Oakland CA US | ||