| 发明名称 | Alpha (1,2) fucosyltransferases suitable for use in the production of fucosylated oligosaccharides | ||
| 摘要 | The invention provides compositions and methods for engineering E. coli or other host production bacterial strains to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection. | ||
| 申请公布号 | US9029136(B2) | 申请公布日期 | 2015.05.12 |
| 申请号 | US201213557655 | 申请日期 | 2012.07.25 |
| 申请人 | Glycosyn LLC | 发明人 | Heidtman Matthew Ian;Merighi Massimo;McCoy John M. |
| 分类号 | C12N1/21;C07H3/06;C12N15/63;C12P19/18;C12N9/10;C12N15/72 | 主分类号 | C12N1/21 |
| 代理机构 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. | 代理人 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. ;Beattie Ingrid A. |
| 主权项 | 1. A method for producing a fucosylated oligosaccharide in a bacterium comprising providing the bacterium comprising an exogenous lactose-utilizing α(1,2) fucosyltransferase enzyme, wherein an amino acid sequence of said enzyme comprises SEQ ID NO:8 and wherein said bacterium produces 2′fucosyllactose (2′-FL). | ||
| 地址 | Waltham MA US | ||